During the rainy season, herbivores graze on the grass-covered pans, whilst in the dry season they can be seen licking salt from the pans. These herbivores in turn attract predators, such as lion, cheetah and leopard. Boreholes have been established at certain points within the reserve in order to encourage wildlife to stay within the area throughout the year.
Giraffe, gemsbok, red hartebeest, eland, kudu, wildebeest, springbok, steenbok, grey duiker, lion, leopard, cheetah, brown hyena, black-backed jackal, bat-eared fox and wild dog can be seen within Khutse, as well as many other smaller mammals. Travellers, however, should not expect to see large herds of game. A wide range of birdlife will keep bird enthusiasts well occupied.